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Scientific Officer – Endocrine Controls Mechanisms

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Location: Chelsea (London)

Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here

Duration of Contract: Fixed Term for 3 years from start date 

Hours per week: 35 hours per week

Job Details

Under the leadership of Professor Cathrin Brisken, we are seeking to appoint a Scientific Officer to provide technical support to the Endocrine Control Mechanisms team.

Prof. Brisken’s team has recently developed new xenograft models that faithfully recapitulate all stages of ER+ breast cancer development and enable analysis of patient-derived tumor cells. You will provide support to the work of the group using novel in vivo and ex vivo patient-derived xenograft models to investigate the molecular mechanisms that promote disease progression, metastasis, and control dormancy and test novel therapeutic approaches.

The successful candidate will be responsible for manipulating patient-derived xenografts (PDXs) genetically by transducing with lentivirus. You will be reporting on datasets generated using in vivo and ex vivo PDX studies, including analysing whole genome sequence data. You will also provide support for in vivo studies. This may include animal handling and health monitoring, xenograft modelling, in vivo imaging, necropsy, and accurate database keeping and maintenance. Experience of working with animals is desirable, together with ability to perform standard laboratory in vitro techniques. Knowledge of cancer biology and familiarity with in vivo models, 3-D cell culture, in vivo imaging, and STR typing would be advantageous, as would programming skills.

You are expected to participate in the day-to-day running of the laboratory, including ordering supplies, maintaining inventories. Additionally, you will provide scientific and technical support for on-going laboratory projects involving histopathology, molecular biology, cell biology and microscopy. This will include generating and analysing data from in vivo and ex vivo experiments, and molecular biology, including cloning, generation of stable cell lines and biochemical techniques and data analysis.

Key Requirements

The successful candidate must have a degree in Biochemistry, Molecular Biology or Cell Biology.

Department/Directorate Information

The Endocrine Control Mechanisms team aims to understand how hormones drive breast cancer development to better prevent the disease and tumour recurrence. Professor Brisken also leads the in vivo modelling programme in the Patient Derived Models team.

The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Cathrin Brisken via email on [email protected] 

To apply please click on the ‘Apply’ button above

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