Location: White City Campus
Applications are invited for a Research Associate in Synthetic Chemistry at Imperial College London. You will join the research group of Dr James A Bull.
The 3-year post is funded by EPSRC to investigate “Small Ring Carbocations for Late-Stage Functionalisation and Medicinal Chemistry”.
The project will develop synthetic chemistry methods and new reagents to incorporate medicinally relevant strained rings, building on recent works. You will take a leading role in the development of new methods and reagents, the establishment of bioisosterism, and the chemoselective functionalisation of medicinally relevant substrates. The reagents will also be applied to the functionalisation of biomolecules. For background and context see, Nature Chemistry 2022, 14, 160; J. Med. Chem. 2023, 66, 12697. You will also work collaboratively with junior group members.
For further details of the research group, see: https://www.imperial.ac.uk/people/j.bull
Duties and responsibilities
You will establish new synthetic methods and reagents for the incorporation of 4-membered heterocyclic rings into medicinally relevant structure and for chemoselective functionalisation of complex substrates. You will be responsible for managing the day-to-day progress of the project, including the design and implementation of appropriate experiments and techniques utilising effective problem-solving skills where necessary. You will work with Dr Bull and members of the research team, work with external collaborators as well as assist in the supervision of junior co-workers in the Bull group.
You will hold, or be near completion of, a PhD in Synthetic Chemistry or have equivalent research, industrial or commercial experience.
Essential criteria include:
- Strong track record in synthetic chemistry or catalysis
- Practical experience in a broad range of techniques including the synthesis of new organic compounds, spectroscopic and chromatographic techniques
- Practical experience of synthetic method development
- Knowledge of modern methods and techniques in synthetic organic chemistry and catalysis
- Knowledge of molecular properties in medicinal chemistry and matched molecular pair analysis
- Ability to design new experiments and include appropriate controls
- Ability to develop and apply new concepts
- Creative approach to problem-solving
- Excellent written and verbal communication skills
- Ability to organise own work with minimal supervision
This is a full time, fixed term position for up to 36 months and you will be based at White City Campus. The project is funded by EPSRC and will start from March 2024.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant.
Candidates should complete the online application.
For additional information please contact Dr James A Bull [email protected]