Campus: Hammersmith
Contract type: Full-time, fixed term for 2 years
Job Summary
Applications are invited for a postdoctoral research position in computational genomics, initially for two years, based in the Functional Gene Control Group (led by Dr Mikhail Spivakov), working in close collaboration with Dr Helle Jørgensen’s team at Cambridge University. We are seeking a motivated computational biologist to deliver an innovative and exciting research project funded by the British Heart Foundation, focusing on the molecular function of vascular smooth muscle cells in cardiovascular disease aetiology. The successful candidate will lead on the integration and conceptualisation of multimodal genomics data arising from single-cell genomics, population genetics and chromosome conformation capture assays using state-of-the-art methodologies and participate in the development of new computational algorithms. The post holder will have a proven track record of genomics research and will receive training in the specific technical and biological aspects of the research project.
The Functional Gene Control group (based within Imperial’s Institute of Clinical Sciences and MRC London Institute of Medical Sciences) studies how enhancers, enhancer-promoter contacts and cis-regulatory networks mediate the effects of disease-linked genetic variants and extracellular signals on gene expression. We are a friendly, interdisciplinary team of wet-lab and computational researchers (and often both) based within MRC London Institute of Medical Sciences in West London. For more information, see the group’s websites at http://functionalgenecontrol.group/ and https://lms.mrc.ac.uk/research-group/functional-gene-control/.
Duties and responsibilities:
- To take initiatives in the planning of research
- To work in close collaboration with in-house and extramural researchers
- To identify and develop suitable techniques for data analysis, integration and visualisation
- To ensure the validity and reliability of data
- To maintain accurate and complete records of all findings
- To write reports for submission to research sponsors
Essential requirements include:
- A PhD in computational biology or another quantitative discipline*
- Experience in statistical analysis and interpretation of large-scale genomic data
- A track record of research in regulatory genomics or statistical genetics
- Experience in collaborating closely with wet-lab researchers and/or hands-on experience of wet-lab work
- Excellent programming skills in Python/R
*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £40,694 – £43,888 per annum.
Further Information:
This position is full-time and fixed-term for two years.
Please contact Dr Mikhail Spivakov ([email protected]) with informal inquiries.
To apply, please click the ‘Apply’ button above.