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Lead Cryo-Electron Microscopy Specialist

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Location: The Francis Crick Institute, Midland Road, London

Short summary

The post-holder for this role will further develop and deliver a state-of-the-art Cryo-EM facility featuring a wide range of Cryo-EM modalities to support Crick science. 

The Crick has excellent Cryo-EM facilities, with two Titan Krios 300kV instruments, one fitted with a Gatan energy filter and K2 detector plus Falcon 4i and the other with a Selectris energy filter and Falcon 4i. These microscopes are complemented by a Talos Arctica 200kV and a Glacios 200kV, both with Falcon 3 detectors, and used for cryo-screening and preliminary data collection, together with two 120kV Spirit TEM microscopes, primarily used for negative-stain. The SB STP is currently installing and commissioning an Aquilos-2 Cryo-FIB instrument and will be incorporating it into our Cryo-ET pipeline.  The Crick also has excellent High Performance Computing resources, with access to dedicated high-speed data storage and CPU and GPU clusters.

Key Responsibilities

  • Lead on the strategic and operational management of the Cryo-EM facility. To train, encourage collaborative research with Crick scientists and develop new techniques, ensuring the service provides state-of-the-art facilities and methodologies to deliver cutting edge science in cryo-EM.
  • Provide expert advice to users on experimental design for Cryo-EM projects, ranging from sample preparation to image processing and structure determination.
  • Engage with the Crick user base to help identify new emerging approaches, current bottlenecks with equipment or staffing, optimise experimental design, data analysis and data sharing.
  • Ensure the safe running of the Cryo-EM facility.  Implement and monitor health and safety processes, develop lab protocols, SOPs, and risk assessments.
  • Manage all operational and capital expenditure pertaining to the Cryo-EM service, writing grant proposals for instrument acquisition, oversight of the procurement process and management of the installation of new equipment. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 17.09.2023
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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